6 . Cosmetics manufacturers and their Responsible Person should closely follow the updates from the SCCS and the amendments to the . Skip to Content. Who should use it: In general, anyone looking to soften their skin with a lightweight product. It can make the. Shorthand nomenclature is based upon the number of siloxane groups in the cyclic structure (Figure 1). Data of the concentration used on cyclomethicone, cyclotrisiloxane, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane from industry survey. Report a problem or mistake on this page. Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane. 4 Free Gifts on $125 | CODE: 27YEARS. Normally, I only buy organic . SAFETY DATA SHEET According to article 31 and Annex II of the EU REACH Regulation Version: 4.4 Revision Date: 07.02.2011 Superseded date: 15.12.2010 XIAMETER(R) PMX-0244 CYCLOTETRASILOXANE 1 of 45 1. D4 can be used in the manufacture of silicone based polymers for use in medical devices and personal care products. Cyclopentasiloxane (D5) can also be harmful to the environment. Potential Cyclotetrasiloxane and Cyclopentasiloxane Health Risks and Concerns. Updated. Some substance identifiers may have been claimed confidential, or may . Skip directly to site content Skip directly to page . testing, monitoring protective equipment 1500+ substances database How often can you use it: Cyclopentasiloxane is safe to use on a daily basis. Compare. (D4). The most severe reported hazards are shown. . These ingredients have the skin/hair conditioning agent function in common. SAFETY DATA SHEET Creation Date 29-Jan-2013 Revision Date 24-Dec-2021 Revision Number 5 1. National Institutes of Health. Under REACH in the EU, cyclotetrasiloxane (D4), cyclopentasiloxane (D5) and cyclohexasiloxane (D6) have been assessed for their potential environmental impact. The aim is to assess their safety and establish restrictions for the protection of human health. Cyclotetrasiloxane, octamethyl-Related Pages. Our database provides you with basic information on more than 1,500 hazardous substances and guides you . We also Provide Trading Suppliers & Manufacture for 68583-49-3 Cyclotetrasiloxane, octamethyl-, reaction products with silica. HHS Vulnerability Disclosure. psoriasis or eczema) or worked occupationally with. Featured community. INCI Name: Cyclotetrasiloxane However, they emphasize potential damage to the lungs through D5 inhalation in aerosols such as hair and sun care sprays. National Library of Medicine. Celebrating 27 Years. Contact. These silicone-based compounds are used in cosmetics to soften, smooth, and moisten. . Cyclotetrasiloxane is a type of silicone that is most often utilized for contributing emollience to a formula and delivering a skin-softening effect in skin care products. 149-227. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. PubMed:An updated state of the science EQC model for evaluating chemical fate in the environment: application to D5 (decamethylcyclopentasiloxane). Just like someone else commented, this name made me look for the safety of this ingredient before reading the rest of the ingredients. This chemical substance is listed in the 2014 update to the Toxic Substances Control Act (TSCA) Work Plan as "octamethylcyclotetra- siloxane" and is assigned CA Index Name "Cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-." It is most commonly referred to as Octamethylcyclotetrasiloxane and will be abbreviated in this document as "D4." The hazmat-based safety product finder. Updated. compounds of the general formula (CH 3) *Compilation of multiple safety data sheets. Is it safe for the. California has also done some looking into this ingredient, and it seems they are also concerned. LOW Cancer LOW Allergies & Immunotoxicity MODERATE Developmental and Reingredientive Toxicity HIGH Use Restrictions Ingredient concerns CONCERNS DATA SOURCES Products with this Ingredient Use restrictions The most recent information indicates that the definition of cyclomethicone has been revised. The European Commission's Scientific Committee on Consumer Safety (SCCS) has issued regulatory guidelines on the use of cosmetics ingredient cyclopentasiloxane (D5) which is commonly used in deodorants, hair sprays, sun blocks and skin care products. 556-67-2: SciFinder nomenclature: Cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-Empirical formula: C 8 H 24 O 4 Si 4: Molar mass: 296.62 g/mol: Appearance: Colorless oily liquid or white solid . Octamethylcyclotetrasiloxane (D4) is a volatile methylsiloxane (VMS) with a relatively low molecular weight. Washington DC. 2.1. 293-51-6 and 556-67-2) is the cyclic dimethyl polysiloxane that conforms to the generic structure for cyclic dimethyl polysiloxane compounds, where n equals 4, and the other components of Cyclomethicone (where n equals 5, 6, or 7) are present at levels of less than 1%. The Skin Deep scoring system was designed to help the public understand whether . Having in mind the safety of direct application or contact by humans with the siloxane (silicone) elastomers, it is necessary to use reactive linear polymers free of contamination with cyclic siloxanes, as well as low molecular polysiloxanes with linear structure. The restriction was based . The attention is drawn into one of the most widely used - Cyclopentasiloxane. As the nation's health protection agency, CDC saves lives and protects people from health, safety, and security threats. RTECS # GZ4397000 CAS # 556-67-2 See: NMAM or OSHA Methods. Cyclosiloxanes are basic members of the broad family of silicone materials. The Cosmetic Ingredient Review Expert Panel concluded that these ingredients are safe in the present practices of use and concentration. kJ/kg . As the nation's health protection agency, CDC saves lives and protects people from health, safety, and security threats. Cyclomethicone (mixture) and the specific chain length cyclic siloxanes (n = 4-7) reviewed in this safety assessment are cyclic dimethyl polysiloxane compounds. Sister chemicals are Octamethylcyclotetrasiloxane . The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Understanding scores. Cyclotetrasiloxane is a cyclic dimethyl polysiloxane. pp. March 2019 . Canadians are reminded when using any product to carefully follow any safety warnings and directions. CAS Reg. Type of ingredient: Emollient, lubricant, and solvent. Advancing Effective, Accountable Policing and Criminal Justice Practices To Enhance Public Trust and Public Safety. PubMed:Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane. But research from Canada in 2008 raised concerns about cyclotetrasiloxane (also called D4) and its sister chemical, "cyclopentasiloxane" (also called D5). Learn more at Paula's Choice. XIAMETER PMX-0244 Cyclotetrasiloxane kJ/kg 172 XIAMETER PMX-0245 Cyclopentasiloxane kJ/kg 157 XIAMETER PMX-0246 Cyclohexasiloxane . HHS Vulnerability Disclosure. 30, pp. Cyclomethicone (mixture) and the specific chain length cyclic siloxanes (n = 4-7) reviewed in this safety assessment are cyclic dimethyl polysiloxane compounds. The major problem is the purity of the silicone - or the lack of it. When the cross-linking reaction involves rubbers contaminated with cyclic . Octamethylcyclotetrasiloxane. The EC Inventory is a combination of three independent European lists of substances from the previous EU chemicals regulatory frameworks (EINECS, ELINCS and the NLP-list). SDS (Safety Data Sheet) Cyclotetrasiloxane, Cyclopentasiloxane, PEG/PPG -18/18 Dimethicone Safety Data Sheet according to Federal Register / Vol. . It is a colorless viscous liquid. Safety Description: S36/37 - Wear suitable protective clothing and gloves. March 2019 . Contact. . Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane . Twitter; Linkedin; 2018 CES - Disclaimer . Both committees concluded that cyclic siloxanes are safe with regard to the present practices of use and their concentrations in PCPs. The EC Number is the numerical identifier for substances in the EC Inventory. Orders Quick Order Custom Products Commerce Solutions. Skip directly to site content Skip directly to page . S61 - Avoid release to the environment. FOIA. Cyclopentasiloxane. Product identifier Product name : OCTAMETHYLCYCLOTETRASILOXANE, 98% Product code : SIO6700.0 Product form : Substance Physical state : Liquid The regulating body also recommended that cyclopentasiloxane should have at least 99% purity with no contamination from cyclotetrasiloxane (D4), a known endocrine disruptor. When used in sunscreen, D6 has been found to harm aquatic life when it rinses off in the oceans. CAS Reg. Customer Support Contact Us FAQ Safety Data Sheets (SDS) Certificates (COA/COO) Quality & Regulatory Calculators & Apps Webinars. When it contains more than 1% of D4 (Cyclotetrasiloxane), which is classified as a reprotoxic substance in the EU. It helps your skin and hair products dry quickly and spread more easily. Common concerns See how this product scores for common concerns. Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches. S46 - If swallowed, seek medical advice immediately and show this container or label. cyclotetrasiloxane " within Products. Department of Health and Human Services. 8600 Rockville Pike, Bethesda, MD, 20894 USA. The basic structure common to all cyclomethicones is a cyclic backbone of siloxane units (i.e., silicon and oxygen with molecules of carbon and hydrogen attached, all very common elements found in nature). . Subsequent to these EU human safety reviews, the United Kingdom submitted a dossier to the European Chemicals Agency (ECHA), proposing a restriction for personal care products that are washed off in normal use if they contain more than or equal to 0.1% by weight of cyclotetrasiloxane (D4) and cyclopentasiloxane (D5). *Compilation of multiple safety data sheets. . Products containing cyclopentasiloxane can be used safely on your hair and skin with minimal personal risk. But, in recent years, questions have been raised about their safety to humans and their effects on the environment. Tuesday, May 31, 2022 . 556-67-2: SciFinder nomenclature: Cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-Empirical formula: C 8 H 24 O 4 Si 4: Molar mass: 296.62 g/mol: Appearance: Colorless oily liquid or white solid . Retain and dispose of contaminated wash water. Details of the supplier of the safety data sheet GELEST, INC. 11 East Steel Road Morrisville, PA 19067 USA Dimethicone and cyclotetrasiloxane differ fundamentally in their physicochemical properties, and as a consequence display different environmental fate paths. testing, monitoring protective equipment 1500+ substances database . Keywords: SCCS, scientific opinion, decamethylcyclopentasiloxane (cyclopentasiloxane, D5), Regulation 1223/2009, CAS n. 541-02-6, EC number 208-764-9 Opinion to be cited as: SCCS (Scientific Committee on Consumer Safety), Opinion on National Institutes of Health. UN IDs: UN 1993: WGK Germany: 1: RTECS: GZ4397000 . A volatile methylsiloxane fluid, clear, odorless, VOC-exempt, low toxicity, low surface tension and evaporates completely at room temperature. On 11 January 2019, the European Chemicals Agency (ECHA) proposed a restriction under the EU's Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) regulation on the use of Cyclotetrasiloxane (D4), Cyclopentasiloxane (D5), and Cyclohexasiloxane (D6) in leave-on cosmetic products at a maximum concentration of 0.1% due to concerns over their persistence in the environment. Cyclotetrasiloxane, octamethyl-Related Pages. RTECS # GZ4397000 CAS # 556-67-2 See: NMAM or OSHA Methods. These ingredients have the skin/hair conditioning agent . 1620 L St NW Suite 1200 Washington DC 20036-4702 phone: 202-331-0651 fax: 202-331-0088 These ingredients have the skin/hair conditioning agent function in common. First, the European Scientific Committee on Consumer Safety (SCCS) deems cyclopentasiloxane in skin care safe. No. PubMed:Ecotoxicity of siloxane D5 in soil. National Center for Biotechnology Information. The Scientific Committee on Consumer Safety (SCCS) has determined that cyclopentasiloxane (D5) (CAS# 541-02-6, EC# 208-764-9) in cosmetic products is safe at the reported concentrations, except for use in hair styling aerosols and sun care spray products.. Cyclopentasiloxane is widely used in cosmetic products due to its unique functions as anti-static, emollient, humectant, solvent, and . 77, No. 1620 L Street, NW, Suite 1200 Washington, DC 20036-4702 ph 202.331.0651 fax 202.331.0088 cirinfo@cir-safety.org Distributed for comment only -- do not cite or quote INTRODUCTION Department of Health and Human Services. You know what - We know how! Cyclopentasiloxane may cause mild skin and eye irritation, according to the ingredient's material safety data sheet, and a small percentage of it reaches systemic circulation through dermal absorption, as found in a study by the Department of Environmental and Radiological Health Sciences. The strict processes in place under these regulations ensure safety for consumers and professional users are well-recognized because Article 56.5(a) of the EU and UK REACH . Refer to special instructions / safety data sheets. It has been noted that the incidence of abortions was increased in sheep eating some clover species due to the presence of compounds that interfere with the interaction between hormones and their target receptors [1,2].Some natural compounds with this effect are well known and most . Policies. 8600 Rockville Pike, Bethesda, MD, 20894 USA. Unpublished data submitted by Personal Care Products Council; 2008 . No. Cyclotetrasiloxane, heptamethylphenyl- | C13H26O4Si4 | CID 25287 - structure, chemical names, physical and chemical properties, classification, patents, literature . They make hair products dry more quickly and deodorant creams slide on more easily. Additionally, the SCCS voiced a concern that D5 may contain trace amounts of cyclotetrasiloxane (D4). S51 - Use only in well ventilated areas. Relevant identified uses of the substance or mixture and uses advised against Use of the substance/mixture : Chemical intermediate For research and industrial use only 1.3. As a consequence, and based on additional safety data, the SCCS revised its Scientific Opinion. D4 (Cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-; Chemical Abstracts Service Registry Number (CASRN) 556-67-2), is a chemical substance for which EPA received a manufacturer request for risk . IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE COMPANY 1.1 Product name : XIAMETER(R) PMX-0244 CYCLOTETRASILOXANE REACH Registration . Other names for Cyclotetrasiloxane Cyclotetrasiloxane partitions into the atmosphere, whereas sediments and soils are the most important environmental compartments for dimethicone.